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Fumaric acid

CAS No. 110-17-8

Fumaric acid( Fumaric acid | Kyselina fumarova | Lichenic acid )

Catalog No. M17809 CAS No. 110-17-8

Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Fumaric acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling.
  • Description
    Fumaric acid is a dicarboxylic acid. It is a oncometabolite or an endogenous, cancer causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears to due to its ability to inhibit prolyl hydroxylase-containing enzymes.
  • In Vitro
    Western Blot Analysis Cell Line:NIH/3T3 Concentration:50 μM Incubation Time:24 h Result:Inhibited p38 MAPK and IκB-a phosphorylation.Attenuated TNF-a-induced NF-κB and decreased the expression of CCR3. Reduced the NF-κB activation induced by TRADD, TRAF2, and MEKK3.
  • In Vivo
    Animal Model:Gestational hypertension rat modelDosage:10 mL/kg Administration:i.v.Result:Downregulated the levels of TET1 and KCNMB1.
  • Synonyms
    Fumaric acid | Kyselina fumarova | Lichenic acid
  • Pathway
    Endocrinology/Hormones
  • Target
    THR
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    110-17-8
  • Formula Weight
    116.1
  • Molecular Formula
    C4H4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (215.39 mM)
  • SMILES
    C(=C/C(=O)O)\C(=O)O
  • Chemical Name
    2-Butenedioic acid (2E)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen X, et al. Fumaric acid production by Torulopsis glabrata: engineering the urea cycle and the purine nucleotide cycle. Biotechnol Bioeng. 2015 Jan;112(1):156-67.
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